PROGENI Parkinson's Research: The Organized Genetics Initiative Parkinson's Research: The Organized Genetics Initiative
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Get Involved in PROGENI
There are two ways in which you can help PROGENI with Parkinson's Disease research. Select one of the options below or to the right to learn more.

Current Studies

Michael J. Fox Foundation Funded Study of Families with a LRRK2 Mutation
PROGENI Family Study
The Michael J. Fox Foundation has recently awarded a grant to Indiana University that will help researchers better understand one of the causes of Parkinson's disease. Our study, the PROGENI Family Study, is part of a larger international consortium that is studying a gene shown to be important in Parkinson's disease, called LRRK2. People who have a defect in the LRRK2 gene will often develop Parkinson's disease. This study is comparing families with and without a defect in the LRRK2 gene and people who may or may not have Parkinson's disease. We are enrolling people who are known to have inherited a LRRK2 mutation.

A goal of this study is to identify early, pre-motor symptoms among individuals who have inherited a defect in the LRRK2 gene. Through an in-person study visit, we hope to identify clinical findings and a laboratory test (or biomarker) that can be used to indicate whether or not an individual will develop Parkinson's disease in the future. Participants will be seen a research center located across the United States, Canada and Puerto Rico. The Study Visit will consist of a brief neurological examination by a movement disorder specialist. Participants will be asked to complete questionnaires designed to obtain more information about symptoms of PD. Participants will be asked to complete a smell test and to provide a sample of blood and urine.

We believe that this is a very important study that provides an excellent opportunity for researchers and families to make a substantial contribution to the understanding of the causes of PD. Understanding the pre-motor symptoms of PD scientists may lead to improved protective therapies as well as a means to identify individuals who are at risk of developing the disease. If you or members of your family are known to have inherited a LRRK2 mutation, please contact us to learn more about this study.

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Phone: 1-888-830-6299

For more information on the LRRK2 gene, read Mutations in LRRK2 - what do they mean and how can we learn more?


Past Studies

Progeni (Closed to Enrollment)
Through the involvement of families with 2 or more individuals with Parkinson’s disease (PD), this research effort has led to many important advances in our understanding of the role of genetics in PD. Already, more than 1,650 individuals with PD, as well as their family members, have participated in this research study. Potential study participants must either be diagnosed with or have symptoms of PD. In addition, they must also have a family history of PD in other relatives.

PROGENI Cares (Closed to Enrollment)
In 2004, the PROGENI study launched a new part of this important research study. We are now recruiting individuals who have PD, regardless of whether or not they have any other family members diagnosed with this devastating disease. Additionally, we are also recruiting "healthy" individuals over the age of 55 to participate in the study as a matched control for someone with PD.



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